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  • Noriko Funayama, Mikiko Nakatsukasa, Tetsutaro Hayashi, Kiyokazu Agata
  • Biology, Medicine
  • Development, growth & differentiation
  • 2005 (First Published: 1 May 2005)
  • In order to investigate the cellular system of the freshwater sponge, Ephydatia fluviatilis, we isolated a molecular marker for the most prominent cell type, the choanocyte. After feeding sponge withContinue Reading
  • Noriko Funayama
  • Biology, Medicine
  • Development Genes and Evolution
  • 2012 (First Published: 1 March 2013)
  • Major questions about stem cell systems include what type(s) of stem cells are involved (unipotent/totipotent/pluripotent/multipotent stem cells) and how the self-renewal and differentiation of stemContinue Reading
  • Noriko Funayama, Mikiko Nakatsukasa, Kurato Mohri, Yoshiki Masuda, Kiyokazu Agata
  • Biology, Medicine
  • Evolution & development
  • 2010 (First Published: 1 May 2010)
  • Little is known about the stem cells of organisms early in metazoan evolution. To characterize the stem cell system in demosponges, we identified Piwi homologs of a freshwater sponge, EphydatiaContinue Reading
  • Kiyokazu Agata, Elizabeth Nakajima, Noriko Funayama, Norito Shibata, Yumi Saito, Yoshihiko Umesono
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 2006 (First Published: 1 August 2006)
  • We propose two major evolutionary origins of stem cell systems in the animal kingdom. Adult pluripotent stem cell systems are found in many invertebrates and probably evolved as components of asexualContinue Reading
  • Noriko Funayama, Mikiko Nakatsukasa, +5 authors Kiyokazu Agata
  • Biology, Medicine
  • Zoological science
  • 2005 (First Published: 1 October 2005)
  • Abstract Sponges (phylum Porifera) have remarkable regenerative and reconstitutive abilities and represent evolutionarily the oldest metazoans. To investigate sponge stem cell differentiation, weContinue Reading
  • Kazuko Okamoto, Mikiko Nakatsukasa, Alexandre Alié, Yoshiki Masuda, Kiyokazu Agata, Noriko Funayama
  • Biology, Medicine
  • Mechanisms of Development
  • 2012 (First Published: 1 March 2012)
  • A hallmark of stem cells is the ability to sustainably generate stem cells themselves (self-renew) as well as differentiated cells. Although a full understanding of this ability will requireContinue Reading