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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice showed delayedExpand
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Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors.
Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis.Expand
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Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.
AIMS In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROSExpand
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Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.
In adipocytes, hydrolysis of triglycerides results in the release of free fatty acids and glycerol. Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water. WeExpand
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Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.
Aquaporin adipose (AQPap), which we identified from human adipose tissue, is a glycerol channel in adipocyte [Kishida et al. (2000) J. Biol. Chem. 275, 20896-20902]. In the current study, weExpand
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Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation ofExpand
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Role of Adiponectin in Preventing Vascular Stenosis
Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity and vascular disease is still unclear.Expand
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Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue
Background—High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenicExpand
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Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
BACKGROUND & AIMS Obesity is one of the risk factors for liver fibrosis, in which plasma adiponectin, an adipocytokine, levels are decreased. Hepatic stellate cells play central roles in liverExpand
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Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages
Background—Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasmaExpand
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