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Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.

• Norihisa Shindo, Kazuki Kumada, Toru Hirota
• Developmental cell
• 2012

Complete dissociation of sister chromatid cohesion and subsequent induction of poleward movement of disjoined sisters are two essential events underlying chromosome segregation; however, how cells… (More)

Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling.

• Yuta Komoike, Akinori Kawamura, +4 authors Toru Higashinakagawa
• Biochemical and biophysical research…
• 2005

We analyzed Polycomb group gene ph2alpha functionally in zebrafish embryos by a gene knock-down procedure using morpholino antisense oligos. Inhibition of ph2alpha message translation resulted in… (More)

Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.

• Daisuke Arai, Hiroaki Katsura, Norihisa Shindo, Mayuko Matsumoto, Toru Higashinakagawa
• Developmental biology
• 2010

The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein… (More)

The ESC-E(Z) complex participates in the hedgehog signaling pathway.

• Norihisa Shindo, Atsushi Sakai, Daisuke Arai, Osamu Matsuoka, Yukihiko Yamasaki, Toru Higashinakagawa
• Biochemical and biophysical research…
• 2005

Polycomb group (PcG) genes are required for stable inheritance of epigenetic states throughout development, a phenomenon termed cellular memory. In Drosophila and mice, the product of the E(z) gene,… (More)

[Histone modification: a new era of targeting epigenetics].

• Norihisa Shindo
• [Rinsho ketsueki] The Japanese journal of…
• 2009

A histone H1 variant is required for erythrocyte maturation in medaka.

• Osamu Matsuoka, Norihisa Shindo, Daisuke Arai, Toru Higashinakagawa
• The International journal of developmental…
• 2008

Three histone H1 variants were identified in medaka fish and their sequence characteristics were analyzed. This paper reports one of these variants, termed H1-2, because of its possible implication… (More)

Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1.

• Makoto Konishi, Norihisa Shindo, Masataka Komiya, Kozo Tanaka, Takehiko Itoh, Toru Hirota
• Biomedical research
• 2018

Separation of sister chromatids is a drastic and irreversible step in the cell cycle. The key biochemistry behind this event is the proteolysis mediated by the ubiquitin ligase called the anaphase… (More)

Participation of Polycomb group gene extra sex combs in hedgehog signaling pathway.

• Norihisa Shindo, Atsushi Sakai, Kouji Yamada, Toru Higashinakagawa
• Biochemical and biophysical research…
• 2004

Polycomb group (PcG) genes are required for stable inheritance of epigenetic states across cell divisions, a phenomenon termed cellular memory. PcG proteins form multimeric nuclear complex which… (More)

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