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  • Andrew X. Zhu, Philip J. Gold, +5 authors Philip Agop Philip
  • Medicine
  • Clinical cancer research : an official journal of…
  • 2013 (First Publication: 15 February 2013)
  • PURPOSE GC33 is a novel recombinant fully humanized monoclonal antibody that binds to human glypican-3 (GPC3). The antitumor activity of GC33 was shown in preclinical models of hepatocellularContinue Reading
  • Ghassan K Abou-Alfa, Chia-Jui Yen, +27 authors Jorge A. Carrasquilo
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • 2017 (First Publication: 1 February 2017)
  • PurposeCodrituzumab, a humanized antibody against glypican-3, is highly expressed in HCC. A phase I study evaluated the combination with sorafenib in HCC.Patients and methodsIn a 3 + 3 design,Continue Reading
  • Oscar Puig, Ya-Chi Chen, +16 authors Reuy-min Lee
  • Medicine
  • 2014 (First Publication: 20 May 2014)
  • e15090 Background: Glypican-3 (GPC3) is an oncofetal protein frequently expressed in HCC. GC33 is a humanized monoclonal antibody against GPC3. Preclinical studies suggested that GC33 triggersContinue Reading