Norifumi Watanabe

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Previous studies have suggested that heparan sulfate proteoglycans (HSPGs) play a role in deposition of beta-amyloid protein (Abeta) in the Alzheimer's disease (AD) brain. In the present study, we demonstrated that glypican-1 can bind fibrillar Abeta, and the binding is mainly mediated by heparan sulfate (HS) chains. Further analysis revealed that(More)
Performing general human behavior by experts' navigation is expected to be realized as wearable and ubiquitous technologies and computing develop. For simple, ordinary behavior, a person does not need the assistance of an expert. However, if one is standing next to an injured/ill person, one needs the instruction on performing first aid treatment from an(More)
Head Mounted Displays (HMDs) are the most popular devices for virtual reality, telexistence/telepresence humanoid operation, and remote behavior navigation. Telexistence/telepresence robot operation is an advanced teleoperation, enabling a human operator to perform remote dexterous manipulation tasks while having the feeling of being present in the remote(More)
Using a defined substrate DNA with a single psoralen interstrand cross-link (ICL), we studied the molecular mechanism of human ICL repair. In vitro ICL repair by human extracts is dependent on replication and is a largely error-free process. Extracts from a human BRCA2-defective mutant cell line, CAPAN-1, are severely compromised in ICL repair.(More)
The title of the session was " Results from Our Collaboration Model " , and it was quite unique since it consisted of research results from different parts of the three research layers. Eeach talk contained many speakers, coming from different laboratories, which is quite unique in Japan. The listeners may have understood how much we have collaborated.(More)