Noriaki Hashimoto

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Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. The human HCC cell lines SK-HEP-1 (SK), HLE, Hep 3B, and HuH-7 were used to induce cancer(More)
This paper proposes an encryption method that uses short keys to enable hierarchical access controls for JPEG 2000 codestreams. The proposed method provides images of various quality levels that may be different from the quality at encoding, though it uses a single codestream and a single managed key (masterkey). Only one key generated from the masterkey is(More)
In contrast to the United States, Japanese patients with chronic hepatitis C currently treated with interferon are generally 10 to 15 years older. Older patients, however, tend to experience more frequent adverse events. This study was conducted to clarify the effect of patient age on the efficacy and safety of combination therapy. We consecutively enrolled(More)
The optimization of our lead GK activator 2a to 3-[(1S)-2-hydroxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide (6g), a potent GK activator with good oral availability, is described, including to uncouple the relationship between potency and hydrophobicity. Following oral administration, this compound exhibited robust glucose(More)
OBJECTIVE The image quality in whole slide imaging (WSI) is one of the most important issues for the practical use of WSI scanners. In this paper, we proposed an image quality evaluation method for scanned slide images in which no reference image is required. METHODS While most of the conventional methods for no-reference evaluation only deal with one(More)
This paper presents an extension of the maximum entropy principle method (MEP), named the extended MEP (EMEP), as a general and practical method for estimating directional wave spectra. Since the EMEP is formulated to consider errors in the cross-power spectra, it proves to be an accurate, reliable, and robust method against such errors. In addition, we(More)
The optimization of a series of benzimidazole glucokinase activators is described. We identified a novel and potent achiral benzimidazole derivative as an allosteric GK activator. This activator was designed and synthesized via removal of the chiral center of the lead compound, 6-(N-acylpyrrolidin-2-yl)benzimidazole. The activator exhibited good PK profiles(More)
Color enhancement of multispectral images is useful to visualize the image's spectral features. Previously, a color enhancement method, which enhances the feature of a specified spectral band without changing the average color distribution, was proposed. However, sometimes the enhanced features are indiscernible or invisible, especially when the enhanced(More)
BACKGROUND Color consistency in histology images is still an issue in digital pathology. Different imaging systems reproduced the colors of a histological slide differently. MATERIALS AND METHODS Color correction was implemented using the color information of the nine color patches of a color calibration slide. The inherent spectral colors of these(More)
High-resolution 3D histology image reconstruction of the whole brain organ starts from reconstructing the high-resolution 2D histology images of a brain slice. In this paper, we introduced a method to automatically align the histology images of thin tissue sections cut from the multiple paraffin-embedded tissue blocks of a brain slice. For this method, we(More)