Noreen P Frawley

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BACKGROUND Surgical and ablative treatment modalities for extramammary Paget's disease (EMPD) have high recurrence rates and can be associated with significant morbidity. OBJECTIVES To evaluate photodynamic therapy (PDT) for the treatment of EMPD. METHODS We conducted a retrospective review of notes and histology of five men with anogenital, groin and(More)
At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness. We report that standard clinical treatment conditions (1 mg/kg Photofrin, light at 630 nm and 150 mW/cm2), which are highly effective for(More)
OBJECTIVE To report the use of wide-area 5-aminolevulinic acid photodynamic therapy to treat numerous basal cell carcinomas (BCCs) and basaloid follicular hamartomas (BFHs). DESIGN Report of cases. SETTING Roswell Park Cancer Institute. Patients Three children with BCCs and BFHs involving 12% to 25% of their body surface areas. Interventions Twenty(More)
BACKGROUND AND OBJECTIVES While basal cell carcinoma (BCC) is effectively treated by several methods, many patients with numerous or frequently occurring lesions seek alternatives that can treat multiple cancers, with improved cosmetic outcome. PDT for esophageal and lung carcinomas is approved at a porfimer sodium (Photofrin) dose of 2 mg/kg, but lower(More)
INTRODUCTION The experience of normal pregnancy is often disrupted for women with preeclampsia (PE). MATERIALS AND METHODS Postal survey of the 112 members of the consumer group, Australian Action on Pre-Eclampsia (AAPEC). RESULTS Surveys were returned by 68 women (61% response rate) and from 64 (57%) partners, close relatives or friends. Respondents(More)
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