Noreen Okwara

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The humoral immune response after acute infection with HIV-1 is delayed and ineffective. The HIV-1 envelope protein gp120 binds to and signals through integrin α4β7 on T cells. We found that gp120 also bound to and signaled through α4β7 on naive B cells, which resulted in an abortive proliferative response. In primary B cells, signaling by gp120 through(More)
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, Laboratory of Immunopathogenesis and Bioinformatics, SAIC Frederick 21702, USA Department of Internal Medicine, Faculty of Medicine, University of Messina, Messina Italy 4 New York University School of Medicine(More)
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