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Superfused strips of the human saphenous vein preincubated with 3H-noradrenaline were used to investigate the influences of serotonin (5-HT) receptor agonists and antagonists on the electrically evoked tritium overflow. 5-HT and the preferential 5-HT1A receptor agonist 8-OH-DPAT [8-hydroxy-2-(di-n-propylamino)tetralin] concentration-dependently inhibited(More)
Strips of human saphenous veins were incubated with [3H]noradrenaline and subsequently superfused with physiological salt solution containing cocaine, corticosterone and propranolol. The electrically (6 Hz) evoked overflow of tritium (78% of which was accounted for by unmetabolized [3H]noradrenaline) was abolished by tetrodotoxin or omission of Ca2+ from(More)
SUMMARY. The highly specific /S-adrenoceptor radioligand, (±)-[ 12! I]iodocyanopindolol, has been used to subclassify /S-adrenoceptors in membranes from human right atrial appendage obtained during open heart surgery. Binding of (±)-[ 125 I]iodocyanopindolol was saturable (Bu,, = 86.4 ± 7.4 fmol (±)-[ 125 I]iodocyanopindolol bound/mg protein, n = 4), of(More)
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