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  • Norbert Pardi, Anthony J Secreto, +14 authors Drew Weissman
  • Medicine, Biology
  • Nature communications
  • 2017 (First Publication: 1 April 2017)
  • Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development and manufacturing. Here we present a safeContinue Reading
  • Norbert Pardi, Steven Tuyishime, +6 authors Drew Weissman
  • Medicine, Chemistry
  • Journal of controlled release : official journal…
  • 2015 (First Publication: 1 November 2015)
  • In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types and tissues needsContinue Reading
  • Hamideh Parhiz, Vladimir V. Shuvaev, +11 authors Vladimir R Muzykantov
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2018 (First Publication: 1 December 2018)
  • ABSTRACT Systemic administration of lipid nanoparticle (LNP)‐encapsulated messenger RNA (mRNA) leads predominantly to hepatic uptake and expression. Here, we conjugated nucleoside‐modified mRNA‐LNPsContinue Reading