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- Éric Rhéaume, Yves Lachance, +7 authors Fernand Labrie
- Molecular endocrinology
- 1991

The 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta HSD) enzyme catalyzes the oxidation and isomerization of delta 5-3 beta-hydroxysteroid precursors into delta 4-ketosteroids, thus leading to the formation of all classes of steroid hormones. In addition, 3 beta HSD catalyzes the interconversion of 3 beta-hydroxy- and 3-keto-5… (More)

- Jacques Simard, Jaques Couet, +5 authors Fernand Labrie
- The Journal of biological chemistry
- 1993

Structures of cDNA clones encoding three members of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family were characterized. To search for potential new types of 3 beta-HSD, rat types I and II 3 beta-HSD cDNAs were used as probes to screen a rat genomic DNA library. Among the clones isolated, one encodes a novel… (More)

- Fernand Labrie, Jacques Simard, +7 authors Yvan de Launoit
- The Journal of steroid biochemistry and molecular…
- 1992

The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyzes the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones. We have recently characterized two types of human… (More)

- Fernand Labrie, Jacques Simard, +7 authors Nora Bretón
- International journal of obesity
- 1991

- Jacques Simard, Michael H . Melner, +4 authors Fernand Labrie
- Molecular and cellular endocrinology
- 1991

The conversion of 3 beta-hydroxy-5-ene steroids by the enzyme complex 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues. To develop a model more closely related to the human, we have isolated and… (More)

- H F Zhao, Jacques Simard, +4 authors Fernand Labrie
- FEBS letters
- 1989

We have used our recently characterized human 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) cDNA as probe to isolate cDNAs encoding bovine 3 beta-HSD from a bovine ovary lambda gtll cDNA library. Nucleotide sequence analysis of two overlapping cDNA clones of 1362 bp and 1536 bp in length predicts a protein of 372 amino… (More)

- Nora Bretón
- 2005

We study the stability of static spherically symmetric exact solutions of Einstein equations coupled with nonlinear electrodynamics, in the magnetic sector. These solutions satisfy the heuristic model proposed by Ashtekar-Corichi-Sudarsky for hairy black holes, meaning that the horizon mass is related to their Arnowitt-Deser-Misner (ADM) mass and to the… (More)

It is addressed the issue of black holes with nonlinear electromagnetic field, focussing mainly in the Born-Infeld case. The main features of these systems are described, for instance, geodesics, energy conditions, thermodynamics. Also it is revised some black hole solutions of alternative nonlinear electrodynamics and its inconveniences.

We present a model for an inhomogeneous and anisotropic early universe filled with a nonlinear electromagnetic field of Born-Infeld (BI) type. The effects of the BI field are compared with the linear case (Maxwell). Since the curvature invaria nts are well behaved then we conjecture that our model does not present an initial big bang singularity. The… (More)

The Aharonov–Anandan and Berry phases are determined for the cyclic motions of a non–relativistic charged spinless particle evolving in the superposition of the fields produced by a Penning trap and a rotating magnetic field. Discussion about the selection of the parameter’s space and the relationship between the Berry phase and the symmetry of the binding… (More)