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Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.
- Nolan R. Mente, A. Wiemer, J. D. Neighbors, J. Beutler, R. Hohl, D. Wiemer
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 February 2007
Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the… Expand
BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G.
- Nolan R. Mente, J. D. Neighbors, D. Wiemer
- Chemistry, Medicine
- The Journal of organic chemistry
- 17 September 2008
The total synthesis of the natural stilbene (+)-schweinfurthin G (8) has been accomplished through a sequence based on an efficient cationic cascade cyclization. This cascade process is initiated by… Expand
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.
- Natalie C Ulrich, John G. Kodet, +4 authors D. Wiemer
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 February 2010
The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or… Expand
Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation
- J. D. Neighbors, Nolan R. Mente, Kelly D. Boss, D. W. Zehnder, D. Wiemer
- Chemistry
- 14 January 2008
Use of a Shi epoxidation for introduction of chirality in a key epoxide intermediate, together with revised protecting group tactics, has allowed an efficient synthesis of the hexahydroxanthene… Expand
Synthesis of trans- and cis-4'-hydroxylomustine and development of validated analytical method for lomustine and trans- and cis-4'-hydroxylomustine in canine plasma.
- L. Dirikolu, T. Chakkath, T. Fan, Nolan R. Mente
- Chemistry, Medicine
- Journal of analytical toxicology
- 1 November 2009
In veterinary medicine, lomustine has been successfull used primarily for the treatment of resistant lymphoma and also for the treatment of mast cell tumors, intracranial meningioma, epitheliotropic… Expand
Relevance of the C-5 position to schweinfurthin induced cytotoxicity.
- Joseph J. Topczewski, M. Callahan, +4 authors D. Wiemer
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 December 2011
The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295,… Expand