• Citations Per Year
Learn More
Ionic liquids (ILs) are a class of diverse organic salts with relatively low melting points (below 100°C) which have attracted considerable interest as a promising "green" substitute for organic solvents. The broad solvation properties of ILs and their high solubility in water, however, present health risks, in particular since it was shown that many ILs(More)
Amyloid plaques comprising misfolded proteins are the hallmark of several incurable diseases, including Alzheimer's disease, type-II diabetes, Jacob-Creutzfeld disease, and others. While the exact molecular mechanisms underlying protein misfolding diseases are still unknown, several theories account for amyloid fiber formation and their toxic significance.(More)
N-methyl-substituted diacylglycerol-indololactones (DAG-indololactones) are newly synthesized effectors of protein kinase C (PKC) isoforms and exhibit substantial selectivity between RasGRP3 and PKCα. We present a comprehensive analysis of membrane interactions and biological activities of several DAG-indololactones. Translocation and binding activity(More)
  • 1