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Nicotinic acetylcholine receptors (nAChRs) are ligand-gated pentameric ion channels that account for the effects of nicotine. Recent genetic studies have highlighted the importance of variants of the CHRNA5/A3/B4 genomic cluster in human nicotine dependence. Among these genetic variants those found in non-coding segments of the cluster may contribute to the(More)
Ethanol consumption produces a wide range of effects on the central nervous system, most of them related to changes in neural receptors. In vitro studies have demonstrated that ethanol increases neural nicotinic acetylcholine receptor (nnAChR) affinity for ACh (Narahashi et al., 1991) and have also reported differences in sensitivity of nnAChRs for ethanol,(More)
The pre-supplementary motor area (pre-SMA) is considered to be a key node in the cognitive control of actions that require rapid updating, inhibition, or switching, as well as working memory. It is now recognized that the pre-SMA is part of a "cognitive control" network involving the inferior frontal gyrus (IFG) and subcortical regions, such as the striatum(More)
A number of studies have reported that ethanol exposure induces changes in different brain systems. The hippocampus is a brain region that is very vulnerable to ethanol exposition, which functionally results in impairment of learning and memory processes reported in heavy drinkers. Hippocampal nicotinic receptors are involved in learning and memory. In this(More)
and Switzerland) in order to assess similarities and differences in four main areas relating to, and influencing, service provision for alcohol use disorders (AUD), service utilisation, impact and cost-effectiveness of brief interventions and specialist treatment for alcohol use disorders. Semi-structured questionnaires were designed for key clinical and(More)
Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic over expression of the alpha 5, alpha 3, beta 4 receptor subunit genes, which lie in a cluster on human chromosome 15, that were(More)
BACKGROUND The objectives of the study were to develop web-based Spanish and Catalan versions of the EQ-5D-Y, and to compare scores and psychometric properties with the paper version. METHODS Web-based and paper versions of EQ-5D-Y were included in a cross-sectional study in Palafolls (Barcelona), Spain and administered to students (n = 923) aged 8 to 18(More)
Background: The objectives of the study were to develop web-based Spanish and Catalan versions of the KIDSCREEN, and to compare scores and psychometric properties with the paper version. Methods: Internet and paper Spanish and Catalan versions of the KIDSCREEN-52 were included in a cross-sectional study in school-age children. Web-based and paper Spanish or(More)
OBJECTIVES To describe the preferences to complete questionnaires via the internet by schoolchildren, as well as to analyze the attitude towards the use of internet to communicate with health professionals. METHODS Cross-sectional study of a school population in Palafolls (Barcelona, n=923) was conducted in October and November 2013. Participants(More)
  • N Robles, Redolar D Ph, +6 authors Pascual‐leone A
  • 2011
Transcranial magnetic stimulation (TMS) is a non invasive technique of brain stimulation which could be an interesting therapeutic tool in addictive disorders, being offline repetitive TMS (rTMS) the main strategy used due to it allows to disrupt underlying brain areas and examine behavioral consequences, (Knoch et al., 2006). There are some evidences that(More)