Thimerosal is a preservative that has been used in manufacturing vaccines since the 1930s. Reports have indicated that infants can receive ethylmercury (in the form of thimerosal) at or above the U.S. Environmental Protection Agency guidelines for methylmercury exposure, depending on the exact vaccinations, schedule, and size of the infant. In this study we… (More)
BACKGROUND In the 1990s, the mercury-based preservative thimerosal was used in most pediatric vaccines. Although there are currently only two thimerosal-containing vaccines (TCVs) recommended for pediatric use, parental perceptions that vaccines pose safety concerns are affecting vaccination rates, particularly in light of the much expanded and more complex… (More)
Toxicokinetic studies were conducted following daily inhalation exposure to methanol vapor prior to and throughout pregnancy in adult female Macaca fascicularis monkeys. They were part of a larger study to investigate the effects of chronic methanol exposure on maternal reproductive performance and early offspring effects. In a two-cohort study design, 48… (More)
Table 1 of this article incorrectly inverted the numbers of animals in the control group and in the 1990s Primate group, listing them as 12 and 16, respectively. The correct number of animals in the control group was 16, and the correct number of animals in the 1990s Primate group was 12. The corrected Table 1 appears in this erratum. In Table S1, the total… (More)
Acknowledgments The authors wish to thank the staff of the Infant Primate Research Laboratory for their cooperation during this study and Dr. David Blough for his assistance with statistical analyses. The authors would also like to thank Dr. John Treanor from the University of Rochester for supplying the vaccines used in the study.
perception of the safety and efficacy of childhood vaccines has a direct impact on immunization rates (Biroscak et al. 2003; Thomas et al. 2004). The current debate linking the use of thimerosal in vaccines to autism and other developmental disorders [Institute of Medicine (IOM) 2001, 2004] has led many families to question whether the potential risks… (More)
The present study was designed to characterize maternal reproductive performance and early offspring effects following exposure to methanol (MeOH) vapor in a nonhuman primate model. The two-cohort study design used 48 adult female Macaca fascicularis (24/cohort) monkeys exposed to 0, 200, 600, or 1800 ppm MeOH vapor for approximately 2.5 h/day, 7 days/week… (More)