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Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired… (More)
Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second generation inhibitor of heat shock protein… (More)
The efficacy of ALK inhibitors in patients with ALK-mutant neuroblastoma is limited, highlighting the need to improve their effectiveness in these patients. To this end, we sought to develop a… (More)
B161 Hsp90 is a widely-expressed molecular chaperone that functions in the maturation and stabilization of cellular proteins. Complexed together with other co-chaperone proteins, Hsp90 catalyzes the… (More)
NSCLC patients carrying oncogenic EGFR mutations initially respond to EGFR targeted therapy. However, duration of the response is limited due to dose limiting toxicities and acquired resistance.… (More)
Biomarkers are increasingly being used in early phase clinical trials not only to determine pharmacodynamic activity but also as surrogate end points of clinical efficacy. BIIB021 is a synthetic… (More)