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Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish.
TLDR
Stable transgenic zebrafish lines carrying a new Wnt/β-catenin signaling reporter, Tcf/Lef-miniP:dGFP, are generated and revealed the transcriptional activities of four Tcf /Lef members controlled by Wnt /β-Catenin signaled during embryogenesis, organ development and growth, and tissue regeneration. Expand
NLK positively regulates Wnt/β‐catenin signalling by phosphorylating LEF1 in neural progenitor cells
TLDR
It is shown that inhibition of Nlk2 function in zebrafish results in decreased Lymphoid enhancer factor‐1 (Lef1)‐mediated gene expression and cell proliferation in the presumptive midbrain, resulting in a reduction of midbrain tectum size. Expand
Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons
TLDR
The FERM domain protein Epb41l5 competes with the Notch ligand Delta as a substrate for Mib1 E3 ligase to coordinate neuronal specification and differentiation at the post-translational level, which suggests that relatively high levels of Delta stabilize Epb 41l5 in NPCs specified as neurons. Expand
Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.
TLDR
It is shown that homeodomain-interacting protein kinase 2 (Hipk2) facilitates protein phosphatase 1 catalytic subunit (PP1c))-mediated dephosphorylation of Dvl via its C-terminal domain and that this deph phosphorylation blocks ubiquitination and consequent degradation mediated by the E3 ubiquitin ligase Itch. Expand
Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury
TLDR
It is suggested that high level of Notch signaling keeps RG quiescent and that appropriate level of notch signaling is required for generation of newborn neurons from RG, as well as in physiological and regenerative conditions. Expand
Role of the ANKMY2-FKBP38 Axis in Regulation of the Sonic Hedgehog (Shh) Signaling Pathway*
TLDR
The findings indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo, and that the regulation ofShh signaling by ANKMY2 is conserved between mammals and fish. Expand
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo
TLDR
In the developing zebrafish embryo, cell competition and elimination of unfit cells are required for proper Wnt gradient formation, which may support tissue robustness and disease prevention. Expand
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning
TLDR
This work shows that a cell competition-related system corrects noisy morphogen gradients in cells that produce unfit morphogen signaling and consequent anterior-posterior patterning and may support tissue robustness and disease prevention. Expand
Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish.
TLDR
Rapamycin improved nucleotide pool imbalance in exosc2-/- zebrafish, resulting in prolonged survival and partial rescue of neuronal defects, and might help explain fundamental molecular mechanisms in neuronal diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. Expand
Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish
TLDR
Findings indicate the involvement of autophagy in the pathogenesis of larsb−/− zebrafish and clarify a mechanistic link between LARS and autophagic in vivo, which could lead to development of new therapeutics for IFLS1. Expand
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