Nobuyuki Nosaka

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INTRODUCTION Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the effectiveness of traditional virus-based strategies. This study was undertaken to evaluate the therapeutic effects of anti-high mobility group box-1 (HMGB1) monoclonal antibody (mAb) treatment(More)
Bordetella pertussis causes life-threatening apnea in infants. Lymphocytosis is an important clue for diagnosis and for determining the severity of pertussis. Antibiotics do not shorten or ameliorate the disease and only decrease the risk of transmission. Antepartum maternal immunization is important for preventing pertussis in infants.
BACKGROUND Pneumatosis cystoides intestinalis, marked by numerous gas-filled cysts in the intestinal wall and submucosa or intestinal submucosa, is a very uncommon condition. CASE PRESENTATION A 79-year-old Asian man presented to our emergency department after 2 days of lower abdominal pain with nausea and constipation. His past medical history included(More)
BACKGROUND Cushing's reflex usually results from intracranial hypertension. Although Cushing's sign can implicate severe traumatic brain injury (TBI) in injured patients, no major investigations have been made. The purpose of this study was to assess the predictability of life-threatening brain injury requiring immediate neurosurgical intervention (LT-BI)(More)
INTRODUCTION Massive bleeding from the thyroid gland causing airway compromise secondary to indirect neck trauma is rare. PRESENTATION OF CASE An 89-year-old woman was transferred to our emergency department due to anterior neck pain after a traffic accident. She had been propelled forward and struck her head on the front mirror during emergency braking.(More)
Up to one third of patients with influenza A (H1N1) virus require intensive care unit (ICU) admission because of severe pneumonia, sepsis, or acute respiratory distress syndrome or a combination of these. Still, in-ICU mortality rate remains excessively high despite the deployment of maximal therapeutic support, often including extracorporeal membrane(More)
BACKGROUND Extracorporeal membrane oxygenation (ECMO) is now a candidate therapy for children with acute respiratory failure. CASE PRESENTATION We report our experience of using central ECMO therapy for acute respiratory distress syndrome followed by seizure in a 15-month-old girl with a severe epileptic disorder. Her respiratory distress was refractory(More)
We report the case of a 12 month-old female diagnosed with acute encephalopathy with biphasic seizures and late reduced diffusion. Epstein-Barr virus DNA was detected in both cerebrospinal fluid (511 copies/mL) and in serum (828 copies/mL) during the early stage of disease, suggesting a role for this virus in pathogenesis.
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