Nobutaka Nakagawa

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To determine whether substance P induces the expression of adhesion molecules ICAM-1 and VCAM-1 on vascular endothelial cells, we examined the effect of substance P, its carboxyl- and amino-terminal peptides, and neurokinin A on the expression of ICAM-1 and VCAM-1 on cultured human umbilical vein endothelial cells (HUVEC). Substance P and the(More)
Many attempts have been made to find novel therapeutic strategies for non-alcoholic steatohepatitis (NASH), while their clinical efficacy is unclear. We have recently reported a novel rodent model of NASH using melanocortin 4 receptor-deficient (MC4R-KO) mice, which exhibit the sequence of events that comprise hepatic steatosis, liver fibrosis, and(More)
To determine the mechanism by which substance P (SP) activates human neutrophils, we examined the potencies of SP, the C-terminal peptides SP4-11 and SP6-11, and the N-terminal peptides SP1-9 and SP1-4 for inducing the increase in cytosolic free Ca2+ concentration ([Ca2+]i), superoxide (O2-) generation, and chemotaxis in human blood neutrophils. SP and the(More)
  • Abe T, Yoshida M Yoshioka, Wakusawa R Tokita-Ishikawa, Seto H, Tamai M, Nishida K Iris +27 others
  • 2012
pigment epithelial cell transplantation for degenerative retinal diseases. Prog Retin Eye Res. KP: Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography. J Biomed Opt. expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche. expressed by putative stem/progenitor(More)
We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an(More)
The currents activated in single cells of an epithelial cell line from renal tubules of Xenopus laevis, were studied, using a whole-cell voltage-clamp technique. After the patched membrane was broken for the whole-cell recording, the currents developed transiently, reaching a peak in 20 min, in cells held under voltage-clamp. The currents did not show(More)
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