Nobuo Okazaki

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Serum concentrations of 5-fluorouracil (5-FU) given by continuous infusion to 19 patients with advanced colonic cancer were measured by an HPLC method, and steady-state concentration (SSc), area under the curve (AUC72) and total body clearance (Cl) were calculated as pharmacokinetic parameters. The serum level of 5-FU rapidly increased, reaching a plateau(More)
During a 7-year period in our hospital, 69 patients with inoperable hepatocellular carcinoma (HCC) underwent 111 courses of transcatheter hepatic artery embolization (TAE) and/or chemoinfusion with lipiodol. Patient survival was 0.5–37 months following therapy and the factors affecting prognosis were evaluated. Survival rates at 1, 2 and 3 years after TAE(More)
OBJECTIVES Dynamic flat panel detectors (FPD) permit acquisition of distortion-free radiographs with a large field of view and high image quality. The present study was performed to evaluate pulmonary function using breathing chest radiography with a dynamic FPD. We report primary results of a clinical study and computer algorithm for quantifying and(More)
By examining the area of defect elucidated on the scintigrams and SPECT (single photon emission computed tomography) images, the extension of the tumor into segments was assessed in cases where the SOL (space-occupying lesion) was determined by other methods. In this study, we followed the Couinaud's segmentation. As a result, it was found that the segment(More)
This study was performed to investigate the ability of breathing chest radiography using flat-panel detector (FPD) to quantify relative local ventilation. Dynamic chest radiographs during respiration were obtained using a modified FPD system. Imaging was performed in three different positions, ie, standing and right and left decubitus positions, to change(More)
Oral fructose tolerance test was performed in 95 patients with liver diseases and 21 normal subjects. The fructose concentration in venous blood was measured with Roe's method in fasting and in 45, 60, 90, 120, and 180 minutes respectively after the oral adminstration of fructose (1 gm/kg of body weight). The highest fructose concentration in venous blood(More)
Cardiopulmonary arrest in pregnancy has a very high maternal and fetal mortality rate. We report a case of successful maternal and neonatal survival in association with emergency cesarean section of a schizophrenic pregnant patient. To our knowledge, this is the first reported case of cardiopulmonary arrest in a pregnant woman with schizophrenia. The(More)
with 5-Fluorouracil (5-FU). AFP levels in the untreated patients went on increasing with progress of clinical illness. On the contrary, the increasing of AFP levels in the treated patients was suspended at the second week after administration of 5-FU and the treated patients had clinical improvement. Sera from 2 patients with hepatoeellular carcinoma which(More)
Serum Triglycerides level in hepatic disease showed high in serum hepatit is and obstructive jaundice, relatively high level in viral hepatitis, and relatively low level in liver cirrhosis. In the course of hepatic disease, Triglycerides showed markedly relat ionship wi th liver functions, and especially S-GOT, S-GPT, bilirubin became normal or marked(More)