Nobuo Miki

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Endothelium-dependent relaxation is markedly reduced in atherosclerotic arteries. Recently, the endothelium-dependent relaxing factor has been identified as nitric oxide (NO). We used RNase protection assay and immunoblotting to elucidate the effect of atherogenic lipoprotein on the expression of constitutive NO synthase (cNOS) mRNA and protein levels in(More)
Since transforming growth factor-beta 1 (TGF-beta 1) has been recently shown to be expressed in the heart by mechanical stretch and ischemic injury, we examined the modulation of c-fos mRNA expression and amino acid uptake by TGF-beta 1 in rat myocardial cells. Pretreatment with TGF-beta 1 potentiated norepinephrine (NE)-induced and stretch-induced (+10%(More)
We report a case of leprosy. A 31-old-phillippine female present with 5 month history of an erythematous plaqe on her right neck. Examination showed 4 erythematous plaques with her. A histological examination of the skin lesion of hir thigh revealed granulomas around nerve and skin appendages which consist of lymphocytes, epidermoid cells and giant cells.(More)
For the purpose of determining exercise intensity required for evaluating the effect of beta-blocking agents, the multi-stage treadmill exercise was carried out up to intensity of 85% of maximal oxygen intake (VO2max) after administration of beta-blocking agents in 7 healthy men. To obtain a stable dose response in the inhibitory effect of beta-blocking(More)
To determine left ventricular early diastolic function and transmitral blood-flow characteristics during periods of sodium depletion (50 mmol/day) and sodium loading (300 mmol/day), Doppler and standard echocardiography were performed in 13 patients with untreated mild hypertension. A high sodium intake for 7 days significantly increased (P less than 0.05)(More)
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