Nobuo Adachi

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Arthroscopic examination before anterior cruciate ligament (ACL) reconstruction sometimes reveals that there is a relatively thick ACL remnant bridging the femur and the tibia that may function to stabilize the knee, although its attachment is not the same as the anatomic site. We have established an ACL augmentation procedure that preserves the ACL remnant(More)
BACKGROUND Interleukin (IL)-17 is an important factor in rheumatoid arthritis (RA) pathogenesis. MicroRNA (miRNA)s are a family of non coding RNAs and associated with human diseases including RA. The purpose of this study is to identify the miRNAs in the differentiation of IL-17 producing cells, and analyze their expression pattern in the peripheral blood(More)
Twenty-six patients with anteroposterior (AP) laxity of the knee, associated with torn anterior cruciate ligament (ACL), were prospectively randomized for arthroscopic lower femoral tunnel placed single- or double-bundle reconstruction using hamstring tendons. We evaluated AP and rotational stabilities under regular loads (a 100-N anterior load and a 1.5-N(More)
We have investigated the correlation between the number of mechanoreceptors in anterior cruciate ligament (ACL) remnants and the joint position sense just before an ACL reconstruction in 29 patients. The number of mechanoreceptors was evaluated histologically, using the Gairns gold chloride method. Mechanoreceptors were also found in patients who had a long(More)
The purpose of present study was to evaluate active mobilization effect of mesenchymal stem cells (MSCs) into injured tissues after intraarticular injection of MSCs, and to evaluate their contribution to tissue regeneration. MSCs, which were obtained from green fluorescent protein (GFP) transgenic Sprague–Dawley (SD) rat and cultivated, were injected into(More)
OBJECTIVES MicroRNAs, a class of noncoding RNAs, play roles in human diseases. MicroRNA-223 (miR-223) is reported to play critical roles in osteoclastogenesis. The purpose of this study was to analyze the expression pattern of miR-223 in rheumatoid arthritis (RA) synovium and examine the suppression of osteoclastogenesis from human peripheral blood(More)
The management of patellar dislocation syndrome has traditionally been difficult. There are no golden standard methods for patellar dislocations probably due to the many etiologies. However, it is known that medial patellofemoral ligament (MPFL) is damaged when the patella is dislocated. The purpose of this study is to examine whether our method of MPFL(More)
PURPOSE The purpose of this study was to evaluate the efficacy of vastus lateralis release for painful bipartite patella. We have also compared the results of open method versus arthroscopic method using a holmium:YAG laser system (OmniPulse Holmium Laser System; Trimedyne Inc, Irvine, CA). TYPE OF STUDY This study was a nonrandomized control and(More)
OBJECTIVE To evaluate the effectiveness of transplanted allogeneic muscle derived cells (MDC) embedded in collagen gels for the treatment of full thickness articular cartilage defects, to compare the results to those from chondrocyte transplantation, and to evaluate the feasibility of MDC based ex vivo gene therapy for cartilage repair. METHODS Rabbit MDC(More)
OBJECTIVE A role of microRNA, which are approximately 22-nucleotide noncoding RNAs, has recently been recognized in human diseases. The objective of this study was to identify the expression pattern of microRNA-146a (miR-146a) in cartilage from patients with osteoarthritis (OA). METHODS The expression of miR-146a in cartilage from 15 patients with OA was(More)