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Flow thresholds for extracellular purine catabolite elevation in cat focal ischemia
- K. Matsumoto, R. Graf, G. Rosner, Nobumitsu Shimada, W. Heiss
- Biology, Medicine
- Brain Research
- 8 May 1992
Ischemic glutamate excitotoxicity may be counteracted by adenosine which appears extracellularly during ischemia as an intermediate purine catabolite and has the potential to modulate glutamate… Expand
Ischemia‐Induced Accumulation of Extracellular Amino Acids in Cerebral Cortex, White Matter, and Cerebrospinal Fluid
- Nobumitsu Shimada, R. Graf, G. Rosner, W. Heiss
- Biology, Medicine
- Journal of neurochemistry
- 1 January 1993
Abstract: In a global model of brain ischemia, accumulation of amino acids was studied in the extracellular space of the auditory cortex and the internal capsule using microdialysis, and in CSF of… Expand
Toxicological approaches to the metabolites of Fusaria. VII. Effects of zearalenone on the uteri of mice and rats.
Purine catabolites in cerebral interstitial fluid during progression of and recovery from ischemia.
The concentrations of purine catabolites in the cerebral interstitial fluid during progression of and recovery from ischemia were studied using brain microdialysis and high-performance liquid… Expand
[Extracellular purine catabolites and tissue nucleotides and purine catabolites during progression and recovery of ischemia].
During progression and recovery of ischemia, extracellular purine catabolites were measured and compared with purine catabolites and adenine nucleotide levels in the tissue. Ischemia was induced by… Expand
Reconfirmation of the specific nature of reticulocytes bioassay system to trichothec mycotoxins of Fusarium spp.
Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex
- Nobumitsu Shimada, R. Graf, G. Rosner, A. Wakayama, C. P. George, W. Heiss
- Chemistry, Medicine
- Journal of cerebral blood flow and metabolism…
- 1 October 1989
Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of… Expand
Differences in ischemia-induced accumulation of amino acids in the cat cortex.
It is well established that excitatory amino acid neurotransmitters are extensively liberated during ischemia and that they have neurotoxic properties contributing to neuronal injury. To study… Expand
Glioblastoma following radiotherapy in a patient with tuberous sclerosis.
- H. Matsumura, H. Takimoto, Nobumitsu Shimada, M. Hirata, T. Ohnishi, T. Hayakawa
- Neurologia medico-chirurgica
- 1 May 1998
A 26-year-old male with tuberous sclerosis developed a glioblastoma in the right temporal lobe 8 years after surgical excision and irradiation of a subependymal giant cell astrocytoma. The… Expand
MR appearance of the persistent hypoglossal artery.
- N. Fujita, Nobumitsu Shimada, H. Takimoto, T. Satou
- AJNR. American journal of neuroradiology
- 1 April 1995
We describe the MR appearance of the persistent hypoglossal artery incidentally found in a case of known glioblastoma multiforme. On the spin-echo images, an abnormal tubular structure of low… Expand