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Writer's cramp, or focal hand dystonia, is characterized by involuntary coactivation of antagonist or unnecessary muscles while writing or performing other tasks. Although the mechanism underlying this muscle overactivation is unknown, recent studies of changes in cerebral blood flow during writing have demonstrated a reduction in the activation of the(More)
OBJECTIVE To study the after-effect of theta burst stimulation (TBS) over the left sensorimotor cortex on the size of somatosensory as well as motor evoked potentials evoked from both hemispheres in healthy human subjects. METHODS We used a continuous TBS paradigm for 40 s (600 pulses) in which a burst of 3 transcranial magnetic stimuli at 50 Hz is(More)
In this paper, we review the state-of-the-art technologies for driver inattention monitoring, which can be classified into the following two main categories: 1) distraction and 2) fatigue. Driver inattention is a major factor in most traffic accidents. Research and development has actively been carried out for decades, with the goal of precisely determining(More)
OBJECTIVE A general lack of longitudinal studies on interhemispheric interactions following stroke led us to use transcranial magnetic stimulation (TMS) to examine changes in corticospinal/intracortical excitability and transcallosal inhibition over a 1-year period following subcortical stroke. METHODS We measured TMS parameters such as motor threshold(More)
We assessed the influence of aging on cardiac function by means of parameters measured by echocardiography. The study group consisted of 494 normal subjects aged 13 to 87 years. We measured the ratio of early filling (E) and atrial contraction (A) transmitral flow velocities (E/A) of left and right ventricular inflow (LV E/A and RV E/A) for assessment of(More)
BACKGROUND Hematuria can be classified as either glomerular or nonglomerular, depending on the bleeding source. We recently reported that urinary albumin-total protein ratio is potentially useful for identifying the source of hematuria. STUDY DESIGN Diagnostic test study. SETTING & PARTICIPANTS 579 fresh urine specimens with microhematuria (> or =5 red(More)
OBJECTIVE To investigate the after-effects of theta burst TMS (TBS) on cortico-muscular synchronization, and on cortico-spinal excitability, in humans. METHODS We studied 10 healthy subjects using a continuous paradigm of TBS (cTBS), i.e. 600 pulses in 40s. Before and after the cTBS, coherence function was computed as a measure of cortico-muscular(More)
The purpose of the present study was to develop a communication aid device utilizing event-related potentials (ERPs) for patients with severe motor disabilities. Preliminary experiments were performed on eight healthy volunteers to determine the optimal methods of presentation of visual stimuli and an off-line analysis of electroencephalography signals.(More)
In previous experimental studies on the visual processing in vertebrates, higher-order visual functions such as the object segregation from background were found even in the retinal stage. Previously, the “linear–nonlinear” (LN) cascade models have been applied to the retinal circuit, and succeeded to describe the input-output dynamics for certain parts of(More)