Nobuhito Kimura

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Limited systematic data on herb-drug interaction are available, despite many opportunities to concomitant use of herb with prescribed drugs. We investigated the effects of 15 herbal extracts in dietary supplements on CYP2C9, CYP2D6 and CYP3A4 activities in human liver microsomes. Strong inhibition of these CYP activities was found by the addition of green(More)
A new ent-clerodane diterpene, named bacchariol (1) was isolated from the aerial parts of Baccharis gaudichaudiana DC. (Compositae), together with known ent-clerodane diterpenes (2, 3), eight known flavonoids (4-11) and 3, 5-dicaffeoylquinic acid (12). Their structures were determined by spectroscopic analyses. Flavonoids (7, 8, 11) and 12 showed moderate(More)
The authors investigated the clinical and radiological features and the treatment strategy for bone metastasis from a rare tumor, intracranial meningeal hemangiopericytoma. The clinical presentations and characteristic imagings were retrospectively reviewed in 15 bony metastatic lesions of four patients with this tumor. All four cases were initially(More)
In this work we will use digital images to compute the entropy dependence on temperature of a nematic lyotropic sample. The set of images comprehend the entire temperature range between a reentrant nematic isotropic phase transition, at a low temperature, and a usual nematic isotropic phase transition at a higher temperature. We will show that, inside the(More)
In this work, through the Z-scan technique, we report on measurements of the nonlinear refractive index (n{2}) in discotic and calamitic nematic phases at room temperature in lyotropic mixtures of potassium laurate, decanol and D(2)O . This technique presents high sensitivity when compared to conventional interferometry. The nonlinear optical birefringence(More)
In this paper, we will study theoretically and experimentally the anisotropy of the thermal diffusivity in nematic liquid crystals. We will show that the Baalss-Hess conformal transformation [D. Baalss and S. Hess, Phys. Rev. Lett. 57, 86 (1986)], can be used to obtain a free of adjustable parameters equation that describes the anisotropy of the heat(More)
The phase diagram is an interesting field of research, particularly in lyotropic liquid crystals (LLC). In this way, one of the most important phase diagrams of this LLC system was reported by Yu and Saupe. Two uniaxial (calamitic--N(C) and discotic--N(D)) and one biaxial nematic (N(B)) phases were determined by these authors. Furthermore, in this phase(More)
We analyzed low molecular weight organic acids and aldehydes in throughfall under pine forest, and organic acids in dew on chemically inert surfaces and pine needle surfaces at urban- and mountain-facing sites of pine forest in western Japan. Low molecular weight organic acids and aldehydes accounted for less than 5% of the dissolved organic carbon in(More)
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