Nobuhiro Okada

Learn More
Tumor suppressor Lats2 is a member of the conserved Dbf2 kinase family. It localizes to the centrosome and has been implicated in regulation of the cell cycle and apoptosis. However, the in vivo function of this kinase remains unclear. Here, we show that complete disruption of the gene encoding Lats2 in mice causes developmental defects in the nervous(More)
Accurate coordination between chromosome segregation and cytokinesis by various mitotic kinases, such as Aurora, prevent tetraploidization and subsequent tumorigensis. The tumor suppressors Lats1 and Lats2 are serine/threonine kinases that localize to the centrosome and regulate cell cycle progression and apoptosis. In the present study, Aurora A was(More)
In recent years, lasers are used widely in fields such as measurements, communications, and medical cares. In those fields, a device for scanning a laser beam quickly and exactly is required. In the field of measurements in particular, laser beam scanners which use a motor driven mirror such as galvanometer mirror or a polygon mirror have been employed.(More)
The tumor suppressors Lats1 and Lats2 are mediators of the Hippo pathway that regulates tissue growth and proliferation. Their N-terminal non-kinase regions are distinct except for Lats conserved domains 1 and 2 (LCD1 and LCD2), which may be important for Lats1/2-specific functions. Lats1 knockout mice were generated by disrupting the N-terminal region(More)
Power-assist robots are expected to assist the motion in daily living of physically weak persons. The concept of perception-assist has been proposed to assist the sensory ability in addition to the assist of motor ability of the user. In the perception-assist for a lower-limb power-assist robot, perception-assist can be applied to avoid the unexpected(More)
LATS2 (Large tumor suppressor 2), a member of the conserved AGC Ser/Thr (S/T) kinase family, is a human tumor suppressor gene. Here, we show that in response to ultraviolet radiation, Lats2 is phosphorylated by Chk1 at Ser835 (S835), which is located in the kinase domain of Lats2. This phosphorylation enhances Lats2 kinase activity. Subsequently, Lats2(More)
Vision guide for a manipulator has been one of the major research issues in robotics. Coordination schemes of visuo-motor systems can be classified on the basis of the knowledge about manipulator kinematics and camera parameters. Many researchers have proposed a number of systems that deal with unknown manipulator kinematics and unknown camera parameters.(More)
Proper response to DNA damage is essential for maintaining the integrity of the genome. Here we show that in response to ultraviolet (UV) radiation, the Lats2 tumor suppressor protein is phosphorylated predominantly by Chk1 and weakly by Chk2 at S408 in vivo, and that this process occurs at all stages of the cell cycle and leads to phosphorylation of(More)
This article proposes multiple self-organizing maps (SOMs) for control of a visuo-motor system that consists of a redundant manipulator and multiple cameras in an unstructured environment. The maps control the manipulator so that it reaches its end-effector at targets given in the camera images. The maps also make the manipulator take obstacle-free poses.(More)
This paper proposes multiple self-organizing maps (SOMs) for control of a visuo-motor system that consists of a redundant manipulator and multiple cameras in an unstructured environment. The maps control the manipulator so that it reaches its end-effector to targets given in the camera images. Also the maps make the manipulator take obstacle free poses.(More)