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The accurate measurement of extragalactic distances is a central challenge of modern astronomy, being required for any realistic description of the age, geometry and fate of the Universe. The measurement of relative extragalactic distances has become fairly routine, but estimates of absolute distances are rare 1. In the vicinity of the Sun, direct geometric(More)
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no single gene accounts for >1-2% of cases. The clinical presentation, behavioural symptoms, imaging and histopathology findings are strikingly heterogeneous. A more complete understanding of autism can be obtained by examining multiple genetic or behavioural mouse models(More)
In the development of the olfactory system, olfactory receptor neurons (ORNs) project their axons from the olfactory epithelium (OE) to the olfactory bulb (OB). The surface of the OB is covered by the central nervous system (CNS) basal lamina. To establish this connection, pioneer axons of the ORNs penetrate the CNS basal lamina at embryonic day 12.5 in(More)
Autism spectrum disorders (ASDs) have garnered significant attention as an important grouping of developmental brain disorders. Recent genomic studies have revealed that inherited or de novo copy number variations (CNVs) are significantly involved in the pathophysiology of ASDs. In a previous report from our laboratory, we generated mice with CNVs as a(More)
For evaluation of the most comfortable position (MCP) in edentulous subjects, as decided by mandibular position sense, the MCP was recorded in ten edentulous subjects and compared with the intercuspal position (ICP) of normal dentate persons. It was found that the MCP was at a lower mandibular position than the ICP; the facial height was markedly reduced in(More)
Paternally and maternally inherited deletions and duplications of human chromosome 15q11-13 are relatively common in the human population. Furthermore, duplications in the 15q region are often associated with autism. Both maternal and paternal interstitial 15q11-13 duplication mouse models have been previously created, where several behavioral differences(More)
Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%–2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some(More)
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