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The transcriptionally active fragment of the yeast RNA polymerase II transcription elongation factor, TFIIS, comprises a three-helix bundle and a zinc ribbon motif joined by a linker region. We have probed the function of this fragment of TFIIS using structure-guided mutagenesis. The helix bundle domain binds RNA polymerase II with the same affinity as does(More)
Many proteins involved in eukaryotic transcription are similar in function and in sequence between organisms. Despite the sequence similarities, there are many factors that do not function across species. For example, transcript elongation factor TFIIS is highly conserved among eukaryotes, and yet the TFIIS protein from Saccharomyces cerevisiae cannot(More)
This paper reports the result of a study on a multiplexing scheme for digital data transmission and switching which can handle both anisochronous and isochronous data traffic of various mix, mainly in one 1,544 kb/s digital channel. The study aims t o determine a unified scheme which is economical and flexible for inter-city heavy traffic data links in the(More)
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