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Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho GTPase in cells. Recently, we identified p115RhoGEF, one of the guanineExpand
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Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
G protein-mediated signal transduction can transduce signals from a large variety of extracellular stimuli into cells and is the most widely used mechanism for cell communication at the membrane. TheExpand
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Regulation and Physiological Functions of G12/13-Mediated Signaling Pathways
Accumulating data indicate that G12 subfamily (Gα12/13)-mediated signaling pathways play pivotal roles in a variety of physiological processes, while aberrant regulation of this pathway has beenExpand
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Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation
Heterotrimeric G proteins and protein kinase A (PKA) are two important transmitters that transfer signals from a wide variety of cell surface receptors to generate physiological responses. TheExpand
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RGS16 inhibits signalling through the G alpha 13-Rho axis.
G alpha 13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF. Activated Rho induces numerous cellular responses, including actin polymerization, serum responseExpand
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Critical Role of Lysine 204 in Switch I Region of Gα13 for Regulation of p115RhoGEF and Leukemia-Associated RhoGEF
Heterotrimeric G proteins of the G12 family regulate the Rho GTPase through RhoGEFs that contain an amino-terminal regulator of G protein signaling (RGS) domain (RGS-RhoGEFs). Direct regulation ofExpand
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RGS16 inhibits signalling through the Gα13–Rho axis
Gα13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF. Activated Rho induces numerous cellular responses, including actin polymerization, serum response elementExpand
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Activation of Leukemia-associated RhoGEF by Gα13 with Significant Conformational Rearrangements in the Interface*
The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled receptor-mediated signaling systems.Expand
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G protein-dependent basal and evoked endothelial cell vWF secretion.
von Willebrand factor (vWF) secretion by endothelial cells (ECs) is essential for hemostasis and thrombosis; however, the molecular mechanisms are poorly understood. Interestingly, we observedExpand
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Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1.
Rho GTPases are integral to the regulation of actin cytoskeleton-dependent processes, including mitosis. Rho and leukemia-associated Rho guanine-nucleotide exchange factor (LARG), also known asExpand
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