Nobuakiya Takeda

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Antiplatelet agents, sarpogrelate (SAR), a 5-HT(2A) receptor antagonist, and cilostazol (CIL), a phosphodiesterase III (PDE-III) inhibitor, are used for the treatment of peripheral vascular disease. We tested whether these agents affect cardiac function and subcellular remodelling in congestive heart failure (CHF) induced by myocardial infarction (MI).(More)
Phospholipase D (PLD) activity associated with the myocardial cell membrane (sarcolemma, SL) specifically hydrolyzes phosphatidylcholine to form phosphatidic acid (PtdOH). As reported for other cells, SL PLD is coupled to a PtdOH phosphohydrolase for the coordinate production of a sn-1,2-diacylglycerol (DAG) pool originating from phosphatidylcholine (t).(More)
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