Noboru Nakamichi

Learn More
BACKGROUND Accumulating evidence indicates that interleukin-8 (IL-8) plays a major role in the mucosal inflammation caused by Helicobacter pylori infection. The purpose of the present study was to examine whether Lactobacillus gasseri OLL2716 (LG21) can inhibit the H. pylori-induced production of IL-8. METHODS A coculture system including MKN45 cells, H.(More)
Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. Tumor cells are exposed to higher oxidative stress compared to normal cells. Numerous reports have demonstrated that the intracellular redox (oxidation/reduction) state is closely associated with the pattern of VEGF expression. Electrolyzed reduced water (ERW) produced near(More)
There are few reports on the physiological effects of metal nanoparticles (nps), especially with respect to their functions as scavengers for superoxide anion radical (O2(.-)) and hydroxyl radical (.OH). We tried to detect the scavenging activity of Pt nps using a hypoxanthine-xanthine oxidase system for O2(.-) and using a Fenton and a UV/H2O2 system for(More)
Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to(More)
Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells. Hita Tenryosui Water(®) (Hita T. W., Hita, Japan) and(More)
Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional(More)
WebTracer is a new usability evaluation environment that supports recording, replaying, and analysis of a gazing point and operation while a user is browsing a website. WebTracer can record a user's gazing point and operation compactly. Results of an experimental evaluation showed that the size of the operation history recorded by WebTracer was from 1/10 to(More)
The purpose of this research is to detect low usability web pages from the behavior of users, such as browsing time, mouse movement and eye movement. We experimented to investigate the relation between the quantitative data viewing behavior of users and web usability evaluation by subjects. We analyzed the data to detect low usability web pages using(More)
Aging-related neurodegenerative disorders are closely associated with mitochondrial dysfunction and oxidative stresses and their incidence tends to increase with aging. Brain is the most vulnerable to reactive species generated by a higher rate of oxygen consumption and glucose utilization compared to other organs. Electrochemically reduced water (ERW) was(More)
This paper describes a WWW site evaluation tool, WebTracer, which can record user's gazing points, a user's operational data, and the screen image of browsed pages. In addition, the WebTracer can replay a user's browsing operations. In an evaluation experiment, we record without interruption, a user's browsing operations using WebTracer. The average(More)