Noble Thomas

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Eighteen potential penetration enhancers, some at concentrations that might be used for that purpose, have been examined to evaluate their irritancy potential on nude mouse skin. A biopsy technique was employed followed by histological examination. Up to 50% glycerol, 10% hydroxyethyl lactamide (HELA), 10% oleyl alcohol, 10% Solketal, 10% glycofurol, 100%(More)
The vitamin D status of IDDs was studied in 3 groups of patients who were treated for several months with (i) conventional insulin therapy (group I, n = 17, HbA1 = 10.1 +/- 0.5%); (ii) continuous subcutaneous insulin infusion (CSII, group II, n = 11, HbA1 = 8.9 +/- 0.6%); and (iii) continuous intraperitoneal insulin infusion (CPII, group III, n = 13, HbA1 =(More)
A stable, mild diabetes in rats maintained on a normal laboratory diet was induced by a single i.p. injection of streptozotocin. Irreversible damage of the pancreatic islet B cells was complete by 3 days after treatment and plasma immunoreactive insulin was undetectable throughout the remaining 12-week period of investigation. The diabetes was characterized(More)
A 61-year-old man, with an 8-year history of ulcerative colitis, presented with bleeding per rectum for 4 weeks' duration. Colonoscopy revealed polypoidal neoplasm at the rectosigmoid junction. Histopathology depicted small cell carcinoma. On immunohistochemical staining, chromogranin A and synaptophysin were positive. The tumour was diagnosed as(More)
Perindopril, a new specific and potent inhibitor of angiotensin-I-converting enzyme, was used to evaluate the possible participation of inhibition of the renin-angiotensin system in the development of aminoglycoside-induced renal failure. Kidney function, morphology and biochemistry were evaluated at regular intervals throughout the study. Perindopril was(More)
Perindopril, a new specific and potent inhibitor of angiotensin-I-converting enzyme was used to evaluate the possible participation of the inhibition of the renin-angiotensin system in the development of aminoglycoside-induced renal failure. Kidney function, morphology and biochemistry were evaluated at regular intervals throughout the study. Perindopril(More)
The antitumor drug celiptium (N2-methyl-9-hydroxyellipticinium) is an ellipticine derivative effective in experimental tumors and in man. The major side effect is nephrotoxicity. The impairment of renal function is studied in rats following a single i.v. dose of 20 mg/kg celiptium and a long-term study (day 2 to day 60). A loss of body weight is noted in(More)
A synergistic effect of antibacterial activity has been demonstrated with piperacillin combined with an aminoglycoside. Four groups of 30 female Wistar rats were injected daily for 14 days with either gentamicin 50 mg/kg, or piperacillin 1,000 mg/kg, or both drugs combined; the control group received sodium chloride in solution. In all groups, creatinine(More)
Five insulin treated diabetics were studied on three consecutive days. Overnight variable intravenous insulin infusions were used before each study to maintain normoglycaemia and to calculate the optimal basal insulin infusion rate (1.1±0.1 U/h) which was then kept constant throughout the study day. A standard 400 kCal breakfast with 25 g xylose was given(More)