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Previous nonhuman primate stroke models have employed temporary occlusion of arteries, had limited behavioral testing and imaging, and focused on the short-term outcome. Our goals were 1. to develop a stable model of chronic stroke in the nonhuman primate, 2. to study in vivo the long-term biochemical changes in the area adjacent to the infarct, using(More)
PURPOSE To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) and age- and gender-matched controls. METHODS Thirty adult subjects (15 with mTBI and 15 age- and gender-matched controls) were investigated using a 3T MR scanner. Time since trauma was 0.5 to 29 years(More)
The brain and the spinal cord are contained in a cavity and are surrounded by cerebrospinal fluid (CSF), which provides physical support for the brain and a cushion against external pressure. Hydrocephalus is a disease, associated with disturbances in the CSF dynamics, which can be surgically treated by inserting a shunt or third ventriculostomy. This(More)
Knowledge of normal cerebrovascular volumetric flow rate (VFR) dynamics is of interest for establishing baselines, and for providing input data to cerebrovascular model studies. Retrospectively gated phase contrast magnetic resonance imaging was used to measure time-resolved VFR waveforms from the two internal carotid arteries (ICA) and two vertebral(More)
PURPOSE To quantify the effect of posture on intracranial physiology in humans by MRI, and demonstrate the relationship between intracranial compliance (ICC) and pressure (ICP), and the pulsatility of blood and CSF flows. MATERIALS AND METHODS Ten healthy volunteers (29+/-7 years old) were scanned in the supine and sitting positions using a vertical gap(More)
Intracranial compliance (ICC) determines the ability of the intracranial compartment to accommodate an increase in volume without a large increase in intracranial pressure (ICP). The clinical utilization of ICC is limited by the invasiveness of current measurement. Several investigators attempted to estimate ICC noninvasively, from magnetic resonance(More)
OBJECTIVE To obtain detailed anatomic information on the levator veli palatini (LVP) muscle from magnetic resonance imaging (MRI). Quantitative measures of the configuration of the LVP muscle at rest and during speech activities were obtained. DESIGN Prospective study using MRI of adult subjects with normal velopharyngeal mechanisms to determine anatomic(More)
OBJECTIVE To obtain detailed anatomic and physiologic information on the levator veli palatini muscle from MRI in individuals with repaired cleft palate and to compare the results with those from normal subjects reported by Ettema et al. (2002). DESIGN Prospective study. SETTING University-based hospital. PARTICIPANTS Four men (ages 22 to 43 years)(More)
The objective was to identify changes in quantitative MRI measures in patients with idiopathic normal pressure hydrocephalus (iNPH) occurring in common after oral acetazolamide (ACZ) and external lumbar drainage (ELD) interventions. A total of 25 iNPH patients from two clinical sites underwent serial MRIs and clinical assessments. Eight received ACZ(More)