• Publications
  • Influence
Molecular dynamics of the compensatory response to myocardial infarct.
Myocardial infarct via occlusion of the left anterior descending coronary in rats caused overriding depression in transcription, signal transduction, inflammation and extracellular matrix pathways inExpand
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Toxicokinetics of domoic acid in the fetal rat.
Domoic acid (DA) is a potent neurotoxin that has both marine wildlife and human health impacts, including developmental effects during prenatal exposure in rodent models. However, little is knownExpand
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Domoic acid induced status epilepticus promotes aggressive behavior in rats
Domoic acid (DA), a naturally occurring environmental toxin, has been observed to induce status epilepticus in humans, sea lions and pelicans. In a recent Sprague Dawley rat model, domoic acid dosingExpand
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Hepatic Gene Expression Response to Acute Indomethacin Exposure
AbstractBackground: Rising morbidity and mortality related to the use of NSAIDs has led to the withdrawal of some of these agents and reconsideration of the adverse effects and usage paradigms ofExpand
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Elimination kinetics of domoic acid from the brain and cerebrospinal fluid of the pregnant rat.
Domoic acid (DA) causes neurological effects in multiple species upon exposure, including status epilepticus in pregnant sea lions and an epileptic disease state that commonly develops in juveniles.Expand
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Tissue distribution of amino acid- and lipid-brevetoxins after intravenous administration to C57BL/6 mice.
Brevetoxins produced during algal blooms of the dinoflagellate Karenia are metabolized by shellfish into reduction, oxidation, and conjugation products. Brevetoxin metabolites comprising amino acid-Expand
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Domoic acid induced seizures progress to a chronic state of epilepsy in rats.
  • N. Muha, J. Ramsdell
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 2011
The emergence of an epilepsy syndrome in sea lions poisoned by domoic acid (DA) draws striking parallels to the single case study of temporal lobe epilepsy (TLE) that developed in an 84 yr old manExpand
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Brevetoxin B is a clastogen in rats, but lacks mutagenic potential in the SP-98/100 Ames test.
Brevetoxins are polyether toxins produced by the dinoflagellate Karenia brevis that are released into the air and are known to cause respiratory hemorrhage in manatees and irritation in humans.Expand
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A Cupric Silver Histochemical Analysis of Domoic Acid Damage to Olfactory Pathways Following Status Epilepticus in a Rat Model for Chronic Recurrent Spontaneous Seizures and Aggressive Behavior
The amnesic shellfish toxin, domoic acid, interferes with glutamatergic pathways leading to neuronal damage, most notably causing memory loss and seizures. In this study, the authors utilized aExpand
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Semisynthesis of radiolabeled amino acid and lipid brevetoxin metabolites and their blood elimination kinetics in C57BL/6 mice.
Brevetoxin B (BTX-B), produced by dinoflagellates of the species Karenia, is a highly reactive molecule, due in part to an α,β-unsaturated aldehyde group at the terminal side chain, leading to theExpand
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