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The contractile response to histamine of tracheal muscle was studied in preparations from BSA-sensitized and non-sensitized guinea-pigs. Sensitization did not enhance the overall response to histamine. However, this response showed evidence of acetylcholine participation. In sensitized preparations, atropine (0.1 microM) caused a significant depression of(More)
High levels of nitric oxide are thought to bethe cause of some of the complications associated withdecompensated end-stage liver disease. To assess nitricoxide metabolism in cirrhotic patients, we measured the levels of nitric oxide metabolites(nitrosohemoglobin, methemoglobin, nitrate, and nitrite)in normal subjects, in patients with(More)
OBJECTIVE A number of atypical antipsychotic drugs were demonstrated to have anxiolytic effects in patients and in animal models. These effects were mostly suggested to be the consequence of the drugs' affinity to the serotonin system and its receptors. Asenapine is a relatively new atypical antipsychotic that is prescribed for schizophrenia and for bipolar(More)
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