Nizar A. Mukhtar

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The HIV-1 virion infectivity factor (Vif) is required during viral replication to inactivate the host cell anti-viral factor, APOBEC3G (A3G). Vif binds A3G and a Cullin5-ElonginBC E3 ubiquitin ligase complex which results in the proteasomal degradation of A3G. The Vif PPLP motif (amino acids 161-164) is essential for normal Vif function because mutations in(More)
The development of pulmonary arterial hypertension in the setting of portal hypertension is known as portopulmonary hypertension. Portal hypertension is thought to predispose patients to disturbances in the homeostatic regulation of numerous neurohumoral and vasoactive mediators that induce the development of pulmonary arterial hypertension. Portopulmonary(More)
Hepatitis B (HBV) is prevalent in certain US populations and regular HBV disease monitoring is critical to reducing associated morbidity and mortality. Adherence to established HBV monitoring guidelines among primary care providers is unknown. The purpose of this study was to evaluate HBV disease monitoring patterns and factors associated with adherence to(More)
Hepatitis B (HBV) represents a significant health disparity among medically underserved Asian and Hawaiian/Pacific Islander (API) populations. Studies evaluating adherence to HBV screening and vaccination guidelines in this population are limited. The purpose of this study was to evaluate HBV screening and vaccination practices using both provider(More)
Although hepatitis C (HCV) is associated with diabetes, few studies have examined pre-diabetes in this population. We aimed to evaluate factors associated with pre-diabetes in HCV-infected patients, including direct measurement of insulin action. Ninety-seven non-cirrhotic, non-diabetic and HCV-infected patients underwent clinical evaluation and oral(More)
control of ‘Severe NVUGI bleeding.’ Methods: 16 healthy individuals were randomized to receive pantoprazole 80mg IV bolus followed by infusion at the rate of 8mg/h (Group A, n 8) or pantoprazole with ranitidine 100mg IV bolus followed by infusion at a rate of 12.5mg/h (Group B, n 8) and intragstric pH recording done for 24 h. In addition, 38 patients of(More)
GOALS To evaluate provider knowledge, attitudes and barriers to hepatitis B virus (HBV) care and management practices across diverse primary care settings. BACKGROUND Factors influencing adherence to recommended HBV screening and management guidelines are poorly defined. MATERIALS AND METHODS Providers across various health care settings in San(More)
Studies investigating insulin resistance (IR) in chronic hepatitis C virus (HCV) infection have used surrogate measures of IR that have limited reliability. We aimed to describe the distribution and risk factors associated with IR and its change over time in HCV using direct measurement. One hundred two non-cirrhotic, non-diabetic, HCV-infected subjects(More)
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