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OBJECTIVE Elderly patients undergoing major surgery often develop cognitive dysfunction and the mechanism of this postoperative complication remains elusive. We sought to determine whether postoperative cognitive dysfunction in old mice is associated with the pathogenesis of Alzheimer's disease. DESIGN Prospective, randomized study. SETTING University(More)
The financial and emotional cost of caring for children affected by hypoxic-ischemic encephalopathy (HIE) is enormous, and developing therapeutic strategies to prevent or ameliorate the severity of HI-related brain injury remains a major priority. In the past, supportive management was the mainstay of treatment, but considerable progress has been made in(More)
Extraforaminal lumbar disk herniation is unusual and often undetected by myelography. Four cases were detected by high-resolution computed tomography. They were verified by surgery in one, diskography in one, and by the clinical course in two cases. Metrizamide myelography in two of the three patients was normal. This suggests that CT can accurately detect(More)
Ring lesions are not infrequently noted at the operative site of intracranial tumors at varying intervals of time after surgery. We present a suture granuloma as an unusual cause of such a lesion. Two guidelines that help in the diagnosis and management of these lesions are discussed with emphasis on the value of the precontrast scan.
Muscle-invasive bladder cancer is an aggressive disease associated with high morbidity and mortality. Radical cystectomy is the mainstay of treatment and has evolved since the first reported cystectomy in 1887 to include pelvic lymph node dissection and the creation of increasingly sophisticated urinary diversions, such as neobladders and pouches, which(More)
BACKGROUND Neuroinflammation is a notable hallmark of Alzheimer's disease pathogenesis and can markedly exacerbate amyloid pathology. Celastrol, a pentacyclic-triterpene, has been found to possess anti-inflammatory properties. OBJECTIVE The purpose of this study was to characterize the effects of celastrol on cell viability and amyloid-β (Aβ) peptide(More)
PURPOSE To assess differences in the in-hospital mortality (HM) rate between men and women with unstable angina pectoris (UA) according to age, depression of the ST segment, history of previous acute myocardial infarction (AMI), and risk factors for coronary heart disease. METHODS From October 96 to March 98, 261 patients with UA were selected. Logistic(More)
Radical cystectomy and urinary diversion is the gold-standard treatment for muscle-invasive and high-risk non-muscle-invasive bladder cancer. Ureteroenteric anastomotic stricture is a well-known complication of urinary diversion and is associated with serious sequelae that lead to total or partial loss of kidney function, infectious complications, and the(More)