Nivedita Bhattacharjee

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Homocysteine (Hcy) when injected intranigrally in rat caused parkinsonian behavioural phenotypes and loss of nigral dopaminergic neurons but the underlying mechanisms of neurotoxicity remains elusive. In the present study, we focused on oxidative stress as one of the mechanisms of neurotoxicity in Hcy-induced hemiparkinsonian rat model. Unilateral(More)
One of the intermediates of methionine cycle, the homocysteine (Hcy), elevates in plasma of Parkinson's disease (PD) patients undergoing L-DOPA (3,4-dihydroxyphenylalanine) therapy and has been regarded as a risk factor of the disease. Several evidences pointed out that Hcy causes degeneration of dopaminergic neurons. In rodent, elevated level of Hcy in(More)
While the cause of dopaminergic neuronal cell death in Parkinson’s disease (PD) is not yet understood, many endogenous molecules have been implicated in its pathogenesis. β-phenethylamine (β-PEA), a component of various food items including chocolate and wine, is an endogenous molecule produced from phenylalanine in the brain. It has been reported recently(More)
Inhibition of catechol-O-methyltransferase (COMT), with drugs like tolcapone and entacapone, has been in practice to reduce L-DOPA-induced hyperhomocysteinemia in Parkinson’s disease (PD) patients. During L-DOPA methylation, S-adenosylhomocysteine is produced which is further processed to synthesize homocysteine (Hcy). Hcy has been reported to cause(More)
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