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The mathematical models proposed and studied in the present paper provide a unified framework to understand complex dynamical patterns in vole populations in Europe and North America. We have extended the well-known model provided by Hanski and Turchin by incorporating the diffusion term and spatial heterogeneity and performed several mathematical and(More)
BACKGROUND Exosomes are rich sources of biological material (proteins and nucleic acids) secreted by both tumor and normal cells, and found in urine of urinary bladder cancer patients. OBJECTIVE The objective of the study was to identify interacting exosomal proteins in bladder cancer for future use in targeted therapy. METHODS The Exocarta database(More)
BACKGROUND Urothelial carcinoma (UC) is one of most common genitourinary malignancy and the spectrum of disease ranges from in situ lesions to muscle-invasive cancers. The non-muscle-invasive lesions have tendency to recur or progress to muscle-invasive disease. The study of the immune profile may identify immune determinants associated with high-grade,(More)
Adenocarcinoma of the bladder is a rare tumor. Primary and metastatic adenocarcinomas of urinary bladder are morphologically similar, but histogenetically different. We present two cases, a signet ring cell adenocarcinoma with follow-up and another of glandular adenocarcinoma of urinary bladder. Pathological evaluation and immunohistochemical panel of eight(More)
Urothelial cancer patients are prone to recurrence, and there is no marker to predict which cases become refractory to the immunotherapy given to these patients. Tumour behaviour is decided by the dynamics between the pro- and anti-tumorigenic cytokines. In this study, 27 cytokines were estimated in serum and urine of 72 urothelial cancer patients and 42(More)
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was(More)
We consider a spatially explicit three-species food chain model, describing generalist top predator-specialist middle predator-prey dynamics. We investigate the long-time dynamics of the model and show the existence of a finite dimensional global attractor in the product space, L(2)(Ω). We perform linear stability analysis and show that the model exhibits(More)
While language competition models of diachronic language shift are increasingly sophisticated, drawing on sociolinguistic components like variable language prestige, distance from language centers and intermediate bilingual transitionary populations, in one significant way they fall short. They fail to consider contact-based outcomes resulting in mixed(More)
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