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Self-crosslinked oxidized alginate/gelatin hydrogel as injectable, adhesive biomimetic scaffolds for cartilage regeneration.
- Biji Balakrishnan, Nitin Joshi, A. Jayakrishnan, R. Banerjee
- Medicine, Materials Science
- Acta biomaterialia
- 1 August 2014
Biopolymeric hydrogels that mimic the properties of extracellular matrix have great potential in promoting cellular migration and proliferation for tissue regeneration. The authors reported earlier… Expand
Progress and challenges towards targeted delivery of cancer therapeutics
- D. Rosenblum, Nitin Joshi, Wei Tao, J. Karp, D. Peer
- Biology, Medicine
- Nature Communications
- 12 April 2018
Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively… Expand
Carboxymethyl-chitosan-tethered lipid vesicles: hybrid nanoblanket for oral delivery of paclitaxel.
- Nitin Joshi, Rama Saha, Thanigaivel Shanmugam, B. Balakrishnan, Prachi More, R. Banerjee
- Chemistry, Medicine
- 14 June 2013
We describe the development and evaluation of a hybrid lipopolymeric system comprising carboxymethyl chitosan (CMC), covalently tethered to phosphatidylethanolamine units on the surface of lipid… Expand
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.
Despite considerable advances in prostate cancer research, there is a major need for a systemic delivery platform that efficiently targets anti-cancer drugs to sites of disseminated prostate cancer… Expand
Scale-up of a pan-coating process
- P. Pandey, R. Turton, Nitin Joshi, Elizabeth L. Hammerman, James Ergun
- Medicine, Chemistry
- AAPS PharmSciTech
- 1 December 2006
The purpose of this work was to develop a practical scale-up model for a solvent-based pan-coating process. Practical scale-up rules to determine the key parameters (pan load, pan speed, spray rate,… Expand
Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells.
Current ISC culture systems face significant challenges such as animal-derived or undefined matrix compositions, batch-to-batch variability (e.g. Matrigel-based organoid culture), and complexity of… Expand
Proapoptotic lipid nanovesicles: synergism with paclitaxel in human lung adenocarcinoma A549 cells.
- Nitin Joshi, Thanigaivel Shanmugam, Anubhav Kaviratna, R. Banerjee
- Medicine, Chemistry
- Journal of controlled release : official journal…
- 20 December 2011
The present study focuses on the development and evaluation of phosphatidylserine based proapoptotic lipid nanovesicles (PSN-PTX) as aerosols for synergistic activity with paclitaxel against lung… Expand
Proapoptotic miltefosine nanovesicles show synergism with paclitaxel: Implications for glioblastoma multiforme therapy.
Hexadecylphosphocholine (HePC) or miltefosine based proapoptotic lipid nanovesicles encapsulating paclitaxel for synergistic anticancer effect of paclitaxel and miltefosine in chemoresistant human… Expand
Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases
- Nitin Joshi, Nitesh Shirsath, A. Singh, K. Joshi, R. Banerjee
- Scientific reports
- 18 November 2014
Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that… Expand
Towards an arthritis flare-responsive drug delivery system
Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often fluctuates over time, a local drug delivery… Expand