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Heliox improves lung deposition of inhaled particles when compared with air or oxygen inhalation. We studied the spirometric effects of albuterol nebulized with heliox during emergency room visits for asthma exacerbations. Forty-five patients were randomized to receive albuterol nebulized with oxygen (control) versus heliox (n = 22 control and 23 heliox(More)
This article outlines the antiplatelet and antithrombotic therapy used in contemporary percutaneous coronary interventions. It is a comprehensive review of past and present pharmacologic agents and includes a discussion of the more promising potential future therapies. The clinical trials that provide the basis for the current standard of care are provided,(More)
AIMS Coronary revascularisation based upon physiological evaluation of lesions improves clinical outcomes. Angiographic or visual stenosis assessment alone is insufficient in predicting haemodynamic stenosis severity by fractional flow reserve (FFR) and therefore cannot be used to guide revascularisation, particularly in the lesion subset <70%. Accordingly,(More)
OBJECTIVES We sought to determine the prevalence, predictors, and clinical impact of target lesion calcification in patients undergoing percutaneous coronary intervention (PCI) with newer generation drug-eluting stents (DES) and devices. BACKGROUND Coronary calcification is independently associated with adverse outcomes following PCI. While newer DES and(More)
Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single-center PCI(More)
OBJECTIVES To compare clinical and safety endpoints with use of rotational (RA) and orbital (OA) atherectomy in a large patient population with moderate to severely calcified lesions undergoing percutaneous coronary intervention (PCI). BACKGROUND Coronary artery calcification (CAC) has been recognized as a risk factor for adverse outcomes with coronary(More)
TCT-334 Predictors of Outcomes Among Nonagenarians Undergoing Percutaneous Coronary Intervention: A National Veterans Affairs Database Study Abhishek Sawant, Vasvi Singh, Kevin Josey, Meg Plomondon, Thomas Maddox, Ali Sheikh, Zaid Said, Bharath Rajagopalan, Deepak Bhatt, John Corbelli State University of New York at Buffalo, Buffalo, New York, United(More)
comparable for baseline characteristics including age, gender, diabetes, acute coronary syndrome, congestive heart failure, atrial fibrillation, previous stroke or myocardial revascularisation. Multi-vessel disease was present in 60% of patients, 20.8 % underwent multivessel procedures (with staging in 3.8%) and 12.2% of target lesions were bifurcations.(More)