Nitin B. Charbe

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After the introduction of the highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV) infection is no longer considered an absolute contraindication for solid organ transplantation in patients with end-stage liver disease [1–3]. However, recurrence of hepatitis C virus (HCV) infection after liver transplantation is frequent and may(More)
INTRODUCTION Ritonavir-boosted atazanavir (ATV/r) is a relatively well tolerated antiretroviral drug. However, side effects including hyperbilirubinemia, dyslipidemia, nephrolithiasis and cholelithiasis have been reported in the medium and long term. Unboosted ATV may be selected for some patients because it has fewer gastrointestinal adverse effects, less(More)
We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic(More)
Sir, Some studies have recently shown that concomitant rifampicin administration significantly reduces linezolid concentrations [1–3]. However, it is currently unknown for how long such effect may persist and, most importantly, when linezolid could be safely administered to guarantee optimal drug exposure in patients previously treated with rifampicin.(More)
BACKGROUND Recently, a turbidimetric immunoassay method has been developed for use in the form of a QMS lamotrigine (LTG) commercial immunoassay. This study was designed to evaluate the performance of this immunoassay using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method as the reference. METHODS The performance of QMS was(More)
Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several(More)
Current research in oncology deploys methods that rely principally on two-dimensional (2D) mono-cell cultures and animal models. Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the(More)
BACKGROUND We have developed and validated a high-performance liquid chromatographic method for the simultaneous quantification, in human plasma, of dolutegravir, a new human immunodeficiency virus (HIV) integrase inhibitor, and rilpivirine, a novel HIV nonnucleoside reverse transcriptase inhibitor. METHODS An internal standard (quinoxaline) was added to(More)
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