Nithya Sankaran

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The binding behavior of lumiflavin, a biologically vital ligand, with DNA duplexes containing an abasic (AP) site and various target nucleobases opposite the AP site is studied. Lumiflavin binds selectively to thymine (T) opposite the AP site in a DNA duplex over other nucleobases. Using 1H NMR spectroscopy and fluorescence measurements, we show that(More)
Future electronic systems demand faster, smaller, lighter and thinner products. Embedding Active and Passive components in package size boards is one of the major steps in accomplishing system level miniaturization and multifunctionality. All multifunctional system packages should pay attention to Signal and Power integrity for ensuring proper operation of(More)
In combination with abasic site (AP site)-containing DNAs, potential use of a biotic fluorescence compound, Vitamin B2 (riboflavin), is demonstrated for the fluorescence detection of the thymine (T)-related single-nucleotide polymorphisms. Our method is based on construction of the AP site in DNA duplexes, which allows small ligands to bind to target(More)
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