Nitendra K. Sahu

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Chalcones (1,3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the flavonoid family, which possess a number of interesting biological properties such as antioxidant, cytotoxic, anticancer, antimicrobial, antiprotozoal, antiulcer, antihistaminic and anti-inflammatory activities. Several pure chalcones have been approved for clinical use(More)
This review deals with the antisense technology that, together, forms a very powerful tool to inhibit gene expression and may be used for studying gene function (functional genomics) and for therapeutic purpose (antisense gene therapy). Antisense oligonucleotides block translation of target mRNAs in a sequence specific manner, either by steric blocking of(More)
Malaria with one million deaths and about 500 million new cases reported annually is a challenge to drug therapy and discovery. As current antimalarial therapeutics become increasingly ineffective because of parasitic resistance, there exists an urgent need to develop and pursue new therapeutic strategies. Antimalarial drug development can follow several(More)
The quantitative structure-activity relationship (QSAR) analysis of some synthesized substituted 4-quinolinyl and 9-acridinyl hydrazone derivatives were performed to find out the structural requirements of their antimalarial activities. Various 2D descriptors were calculated and used in the present analysis. The 2D-QSAR studies were performed using three(More)
To identify novel and potent anticonvulsant ligands, initially 2D and 3D-QSAR models were generated using a series some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole as anticonvulsants. Both the QSAR models yielded significant cross-validated q 2 values of 0.67 and 0.81 and predicted r 2 (pred_r 2) values of 0.66 and 0.83 for 2D(More)
A series of spiro-barbiturates has been synthesized using an appropriate synthetic route and characterized by elemental analyses and spectral data. All the synthesized compounds were screened in vivo for their anticonvulsant activity and acute toxicity. All the synthesized compounds were administered at doses of 30, 100, 200, and 300 mg/kg body weight and(More)
The quantitative structure–activity relationship (QSAR) studies were performed on a series of 42 chalcone derivatives to find out the structural requirements of their antimalarial activities. The multiple linear regression (MLR) and partial least square (PLS) regression methods coupled with various feature selection methods, viz., stepwise (SW), genetic(More)
With a view to the rational design of a selected series of 35 imidazopyridazine derivatives, 2D and 3D QSAR models have been developed for the prediction of antimalarial activity. The statistically best 2D QSAR model having r(2) = 0.9242 and q(2) = 0.8691 with pred_r(2) = 0.9206 was developed by SW-MLR and best 3D QSAR model having q(2) = 0.8607 with(More)
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