Nisrine Saadallah

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Whole mount pachytene spreads were used to investigate the pairing of a supposed balanced reciprocal t(4;9) translocation in a human male ascertained for subfertility. All well spread pachytene spermatocytes analysed by light microscopy and electron microscopy contained a hexavalent instead of the expected quadrivalent this suggesting that a third(More)
EM investigations of surface spread synaptonemal complexes of pachytene spermatocytes were performed on a human male carrier of a pericentric inv(13), ascertained through his daughter with a duplication-deficiency of the same chromosome. The inv(13) bivalent could be unambiguously identified by either its asymmetrical kinetochores or its nucleolar(More)
The chiasma distribution of bivalents 15 and 16 identified at diakinesis by a quadruple staining technique including DA-DAPI fluorescence has been investigated in two human males. The study has shown that chiasmata are not distributed at random. Both chromosomes have distally localised chiasmata, but in the long arm of chromosome 15 chiasmata are also found(More)
Chromosomes at first meiosis from two males with the fra(X) form of mental retardation were studied using pachytene surface spreads and air-dried preparations. The pachytene sex bivalents showed no discontinuation of the synaptonemal complex in the terminal part of Xq corresponding to band Xq27-28 of the mitotic chromosomes. In both cases the frequency of a(More)
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