Nishimura Kazuhiko

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BACKGROUND Orotate phosphoribosyl transferase (OPRT) is the initial key enzyme in the 5-FU metabolic pathway. It is an enzyme that converts 5-fluorouracil into 5-fluorouridine monophosphate. We have previously shown that there is a strong positive correlation between OPRT activity and the antitumor effects of 5-FU. In this study, we investigated the(More)
Acquired anticancer drug resistance in cancer cells is often a result of an increase in levels of the ATP binding cassette (ABC) transporters that export anticancer drugs from cancer cells, suggesting that anticancer drugs may induce genes that mediate drug resistance in cancer cells. In this study, the induction of anticancer drug transporter gene(More)
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