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Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor
TLDR
T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. Expand
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
Significance T-cell receptor (TCR) recognition of antigenic peptides presented by major histocompatibility complex (MHC) proteins defines specificity in cellular immunity. Evidence suggests that TCRsExpand
Changing the peptide specificity of a human T cell receptor by directed evolution
Binding of a T cell receptor (TCR) to a peptide/major histocompatibility complex is the key interaction involved in antigen specificity of T cells. The recognition involves up to six complementarityExpand
A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.
TLDR
T-cell receptors (TCRs) have emerged as a new class of therapeutics, most prominently for cancer where they are the key components of new cellular therapies as well as soluble biologics. Expand
Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells
The authors would like to make the following corrections to the published article.
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells
Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We describe preliminary results from a Phase IExpand
Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex*
Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants withinExpand
Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes
T cell specificity emerges from a myriad of processes, ranging from the biological pathways that control T cell signaling to the structural and physical mechanisms that influence how TCRs bindExpand
Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice.
Medullary thyroid carcinoma (MTC) is a neoplasm of the endocrine system, which originates from parafollicular C-cells of the thyroid gland. For MTC therapy, the Food and Drug Administration recentlyExpand
How an alloreactive T-cell receptor achieves peptide and MHC specificity
  • Yuan Wang, Nishant K. Singh, +7 authors B. Baker
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 1 June 2017
Significance T-cell alloreactivity drives transplant rejection. Alloreactive recognition is believed to proceed with limited specificity, accounting for the high numbers of alloreactive T cells inExpand
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