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The structure of the dynactin complex and its interaction with dynein
Making a molecular motor fit for purpose Dynactin is an essential cofactor of the microtubule motor, cytoplasmic dynein. Dynactin contains 23 subunits built around a short filament of an… Expand
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains elusive. To address this question, we profiled… Expand
Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase
- Y. Chen, Nisha A. Patel, Andrew Crombie, J. Scrivens, J. Murrell
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 October 2011
Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria;… Expand
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
- P. A. Seymour, Kristine K. Freude, Claire L. Dubois, H. Shih, Nisha A. Patel, M. Sander
- Biology, Medicine
- Developmental biology
- 1 November 2008
We have previously shown the transcription factor SOX9 to be required for the maintenance of multipotential pancreatic progenitor cells in the early embryonic pancreas. However, the association of… Expand
A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
All mature pancreatic cell types arise from organ-specific multipotent progenitor cells. Although previous studies have identified cell-intrinsic and -extrinsic cues for progenitor cell expansion, it… Expand
Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90
Summary Protein folding in cells is regulated by networks of chaperones, including the heat shock protein 70 (Hsp70) system, which consists of the Hsp40 cochaperone and a nucleotide exchange factor.… Expand
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.
The generation of pancreas, liver, and intestine from a common pool of progenitors in the foregut endoderm requires the establishment of organ boundaries. How dorsal foregut progenitors activate… Expand
Sox9-Haploinsufficiency Causes Glucose Intolerance in Mice
The HMG box transcription factor Sox9 plays a critical role in progenitor cell expansion during pancreas organogenesis and is required for proper endocrine cell development in the embryo. Based on in… Expand
Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance
- A. Lai, E. Clérico, +5 authors L. Gierasch
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 20 April 2017
Proteins are dynamic entities that populate conformational ensembles, and most functions of proteins depend on their dynamic character. Allostery, in particular, relies on ligand-modulated shifts in… Expand
Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex
Summary BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is… Expand