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In vivo models in rodents and primates were used to investigate ways of overcoming the poor oral and rectal absorption of ceftriaxone. The sodium salt of ceftriaxone at 20 mg/kg was formulated in C8-C10 chain length, mono- and diglyceride extracts of coconut oil (Capmul) and administered intraduodenally to adult rats. Peak plasma levels of 17-52(More)
Solid dispersions of artemether (ARM), a poorly soluble drug, were prepared using polyvinylpyrrolidone (PVPK25, MW 25000) and polyethyleneglycol (PEG4000, MW 4000) as excipients. These dispersions were studied by physical mixture, freeze-drying, and melting methods. They were characterized by X-ray diffraction pattern, fourier transform infrared(More)
Sinh-domain CMOS filters have favorable properties, such as a wide dynamic range at low supply voltage, compactness, linearity, and low power consumption. These properties are becoming increasingly important for biomedical applications that require extremely low-power dissipation and neuromorphic circuits that attempt to reproduce the biophysics of(More)
CONTEXT Controlled release (CR) matrix tablet of Prochlorperazine maleate was developed to improve its patient compliance. METHODS Tablet formulations F1, F2 and F3 based on different concentrations of Methocel(®) K100 LV-CR Premium, were compacted by direct compression method while tablet formulations F4, F5 and F6, based on distinct blends of(More)
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