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Comparative Effectiveness and Safety of Medications for Type 2 Diabetes: An Update Including New Drugs and 2-Drug Combinations
BACKGROUND Given the increase in medications for type 2 diabetes mellitus, clinicians and patients need information about their effectiveness and safety to make informed choices. PURPOSE ToExpand
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Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes
Type 2 diabetes and its complications are a substantial public health burden, affecting 9.3% of the U.S. adult population (1, 2). Most patients with type 2 diabetes eventually requireExpand
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Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes Mellitus
BACKGROUND Patients with diabetes mellitus need information about the effectiveness of innovations in insulin delivery and glucose monitoring. PURPOSE To review how intensive insulin therapyExpand
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 controlExpand
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Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes
Context The relative effects of premixed insulin analogues, other insulin regimens, and noninsulin antidiabetic agents for adults with type 2 diabetes are unclear. Contribution This systematic reviewExpand
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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Background Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identifiedExpand
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Diabetes Medications for Adults With Type 2 Diabetes: An Update
Objectives To evaluate the comparative effectiveness and safety of monotherapy and metformin-based combination therapy for type 2 diabetes. Data sources We searched MEDLINE®, Embase®, and theExpand
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Obesity and Mammography: A Systematic Review and Meta-Analysis
BACKGROUNDObese women experience higher postmenopausal breast cancer risk, morbidity, and mortality and may be less likely to undergo mammography.OBJECTIVESTo quantify the relationship between bodyExpand
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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564Expand
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Patient Preferences for the Treatment of Type 2 Diabetes: A Scoping Review
BackgroundAs more studies report on patient preferences, techniques are needed to identify, assess and, eventually, synthesize results from a diverse set of methodologies. Data on patient preferencesExpand
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